Ameloblastomas: diagnosis considerations and therapeutic approaches.

Abstract

Objective: To demonstrate the current considerations in the diagnosis, change in the classification and therapeutic approach, for the treatment of ameloblastomas. Method: it is a narrative review of literature combined with the demonstration of original clinical cases to approximate the revised theoretical content with examples of the practical application of the professional's performance. The literature search was based on world reference books such as the World Health Organization's associated electronic search in the Medline, Lilacs and SciELO databases. Results: Ameloblastoma is a slow, asymptomatic benign odontogenic neoplasm. In terms of imaging exams, the lesions vary from unilocular to multilocular radiolucent, which can cause changes in nearby teeth. In trans-surgical and histopathological aspects, there are differences between ameloblastoma and cystic ameloblastoma for intraosseous lesions, and the treatment will be influenced by this factor, in addition to the patient's age, lesion size and location. There is still a certain preference in the literature for radical approaches. Therapies targeting the BRAF gene look like a promising future. Conclusion: The knowledge of ameloblastoma variants is paramount and guides a therapeutic reflection of the cost/benefit type to be established in each case individually based on multidisciplinary discussion and patient choice.