O PAPEL DA INTERLEUCINA 10 NA INFECÇÃO PELO PAPILOMAVÍRUS HUMANO DE ALTO RISCO ASSOCIADO A CARCINOGÊNESE CERVICAL
DOI:
https://doi.org/10.37951/refacer.v10i1.5946Resumo
Introdução: A história natural do câncer cervical está associada a presença persistente da infecção pelo Papilomavírus humano (HPV) de alto risco. Vários fatores imunológicos, estão envolvidos nesse processo, entre eles a IL-10, uma citocina multifuncional que auxilia na progressão tumoral.Objetivo: Descrever o papel da IL-10 na infecção pelo HPV de alto risco em cânceres do colo do útero. Metodologia: Tratou-se de uma revisão integrativa da literatura, em que foram analisadas publicações indexadas na base MEDLINE, consultadas por meio do PubMed; Biblioteca Virtual de Saúde (BVS) e Scientific Eletronic Library Online (SciELO), e buscadores como Google acadêmico. Resultado e Discussão: Sete estudos foram incluídos na revisão, os quais mostraram que níveis mais altos de IL-10 estão presentes em microambientes tumorais com crescimento celular induzido pelo HPV. A prevalência geral do HPV foi de 85,7%. A principal metodologia de análise da IL-10 foi ELISA, e o tipo histológico tumoral mais encontrado foi o carcinoma de células escamosas (CEC). CONCLUSÃO: A IL-10 tem o papel de ajudar na promoção da carcinogênese induzida por HPV de alto risco em cânceres do colo do útero. Estudos que investiguem o papel da IL-10 associada ao HPV são escassos, mas necessários para traçar um caminho mais claro da atuação da IL-10 na resposta imunológica durante o processo carcinogênico.
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